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Toxicological and hygienic assessment of a combined preparation based on S-metolachlor and terbutylazine and determination of residues of pesticides in soil, grain and oil crop using QuEChERS sample preparation

Toxicological and hygienic assessment of a combined preparation based on S-metolachlor and terbutylazine and determination of residues of pesticides in soil, grain and oil crop using QuEChERS sample preparation

ISSN 2223-6775 Ukrainian journal of occupational health Vol.18, No 3, 2022


https://doi.org/10.33573/ujoh2022.03.204

Toxicological and hygienic assessment of a combined preparation based on S-metolachlor and terbutylazine and determination of residues of pesticides in soil, grain and oil crop using QuEChERS sample preparation

Yastrub T.A., Baranov Y.S., Demchenko V.F., Zaiets E.R.
State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine


 Full article (PDF): ENG / UKR

Introduction. In recent years Ukrainian market of crop protection chemicals is increasingly replenished with mixed preparations, which is an important -hygienic and problem. This requires taking into account the potential risks of the combined toxic effects of the active ingredients of pesticides and developing analytical methods for the simultaneous determination of multiple pesticide residues in environmental objects.

Purpose of the study: toxicological and hygienic evaluation of the mixed herbicide based on S-metolachlor and terbuthylazine at the stage of its state trials on sunflower and corn with the determination of microquantities of active ingredients in the soil, green plants and the harvest of grain and oil crops using QuEChERS sample preparation.

Materials and methods. Literature overview on the toxicological properties of S-metolachlor and terbuthylazine; experimental studies using organoleptic, physico-chemical (chromatographic), sanitary-hygienic methods and statistical analysis. The determination of microquantities of active substances in soil, green plants, and harvested grain and oil crops was carried out using QuEChERS sample preparation.

Results. A toxicological and hygienic evaluation of the mixture herbicide and its active ingredients S-metolachlor and terbuthylazine was carried out, their hazard classes were determined according to toxicity indicators and hygienic criteria. The dynamics of residual amounts of S-metolachlor and terbuthylazine in sunflower and corn were studied. It was established that the application of the method of simultaneous determination of microquantities of S-metolachlor and terbuthylazine in soil, green plants, grain and oilseed crops accelerates the analysis by 4-6 times. Hygienic regulations for the safe use of the herbicide on corn and sunflower were established.

Conclusion. Based on acute inhalation toxicity, which is a limiting toxicity index, the combined herbicide preparation of active ingredients S-metolachlor and terbuthylazine belongs to the 2nd class of danger, highly stable in water. Approved maximum residue levels (MRLs) of S-metolachlor and terbuthylazine in sunflower and corn ensure the safety of the use of this preparation. The application of the QuEChERS sample preparation methodology leads to a significant saving of material and energy resources while maintaining metrological characteristics that meet the requirements of sanitary and hygienic control.

Keywords: mixed pesticide, S-metolachlor, terbuthylazine, toxicity, danger, hygienic regulation, QuEChERS sample preparation.

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