Stabilization of doped titanium-containing nanomaterials in the framework of screening studies of potential hazard for workers and environment
Demetska O.V., Beliuha O.G., Movchan V.O., Patyka T.I., Tsapko V.G.
State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
Full article (PDF): ENG / UKR
Introduction. Doping with heavy metals can increase the initial toxicity of the nanomaterial, and cause adverse effects on environment and workers health.
The purpose of research. To analyze the dispersion of hydrosols of nanopowders of doped titanium-containing nanomaterials in different environments and to substantiate the feasibility of stabilizers for a series of screening studies of potential hazards.
Materials and methods of research. The dimensionality of titanium dioxide complex doped with silver (TіO2+Ag nanocomposite, mass fraction of Ag~4%), titanium dioxide complex doped with silver (TiO2+Ag nanocomposite, mass fraction of Ag~8%), and titanium dioxide nanopowder (TіO2) in different environments / stabilizers was estimated. The particle size was determined by dynamic light scattering using an Analysette 12 DynaSizer (Fritsch, Germany).
Results. Stabilization of titanium nanopowders with a glucose-citrate buffer makes it possible to obtain relatively stable hydrosols that can be used in screening studies using bovine spermatozoa as a test object. For studies of phyto- and antibacterial toxicity, it is advisable to use nanopowders in physiological solution.
Conclusions. In-depth investigations on the potentially toxic effects of additional doping of nanopowders with heavy metals on workers health and environment are needed.
Keywords: titanium-containing nanomaterials, doping, stabilization, screening, dispersion.
References
- Carofiglio, M., Barui, S., Cauda, V., Laurenti, M. (2020), «Doped Zinc Oxide Nanoparticles: Synthesis, Characterization and Potential Use in Nanomedicine", Appl Sci (Basel), No. 10(15), pp. 5194, https://doi.org/10.3390/app10155194
- Mehtab, A., Ahmed, J., Alshehri, S. M., Mao, Y., Ahmad, T. (2022), "Rare earth doped metal oxide nanoparticles for photocatalysis: a perspective", Nanotechnology, Jan 12, No. 33(14), https://doi.org/10.1088/1361-6528/ac43e7
- Díez-Pascual, AM. (2018), "Antibacterial Activityof Nanomaterials", Nanomaterials (Basel), No. 8(6), pp. 359, https://doi.org/10.3390/nano8060359
- Park, J.H., Kim, Y.J., Binn, K, Seo, K.H. (2018), "Spread of multi drug resistant Escherichia coli harboring integrin via swine farm waste water treatment plant", Ecotoxicol Environ Saf., No. 149, pp. 36-42, https://doi.org/10.1016/j.ecoenv.2017.10.071
- Lu, N., Zhu, Z., Zhao, X., Tao, R., Yang, X., Gao, Z. (2008), "Nano titanium dioxide photocatalytic protein tyrosine nitration: a potential hazard of TiO2 on skin". Biochem Biophys Res Commun, No. 370(4), pp. 675-680. https://doi.org/10.1016/j.bbrc.2008.04.010
- Demetska, O.V., Didenko, M.M., Movchan, V.O., Beliuha, O.G., Riabovol, V.M., Leonenko, O.B. (2021), "Screening assessment of the damaging effect of nanomaterials using bull sperm as a test object", South Ukrain ianmedical scientific journal, No. 1, pp. 12-18.
- Riabovol, V., Kurchenko, A., Yavorovskyi, A., Savchenko, V., Taran, N. (2021), "A study of the influence of photoactive titanium composite nanoparticles of the functional activity of cytokine-producing mononuclear blood cells in vitro", Immunology and allergology: science and practice, No. 3, pp. 23-20. https://doi.org/10.37321/immunology.2021.3-03
- Özkan, Y., İrende, İ., Akdeniz, G., Kabakcı, D., Sökmen, M. (2015), "Evaluationofthe Comparative Acute Toxic Effectsof TiO2, Ag-TiO2 and ZnO-TiO2 Composite Nanoparticleson Honey Bee (Apismellifera)", Journal of International Environmental Application& Science, No. 1 (10), pp. 26-36
- Phan, H.T., Haes, A.J. (2019), "What Does Nanoparticle Stability Mean?", J Phys Chem C Nanomater Interfaces, Jul 11, No. 123(27), pp. 16495-16507, https://doi.org/10.1021/acs.jpcc.9b00913
- La Spina, R., Mehn, D., Fumagalli, F., Holland, M., Reniero, F., Rossi, F., Gilliland, D. (2020), "Synthesis of Citrate-Stabilized Silver Nanoparticles Modified by Thermal and pHP reconditioned Tannic Acid", Nanomaterials (Basel), Oct 15, No. 10(10), pp, 2031, https://doi.org/10.3390/nano10102031
- Ju, X., Fučíková, A., Šmíd, B., Nováková, J., Matolínová, I., Matolín, V., Janata, M., Bělinová, T., Hubálek Kalbáčová, M. (2020), "Colloidal stability and catalytic activity of cerium oxide nanoparticles in cell culture media", RSC Adv, Oct 27, No.10(65), pp. 39373-39384, https://doi.org/10.1039/D0RA08063B
- Levchenko, O.G., Lukyanenko, A.O., Demetska, O.V. (2019), "The influence of the composition of the binding coating of electrodes on the toxicity of welding aerosols", Automatic welding, No. 7, pp. 33-37.