National University of Life and Environmental Sciences of Ukraine, Kyiv, Ukraine
Introduction. Widespread use of pesticides in various spheres of human life leads to negative consequences for humans.
The aim of the research – to investigate the microelement composition of the liver and kidneys of rats exposed to acute exposure to pesticides (fungicides) containing one or more active ingredients.
Materials and methods of the research. The content of chemical elements was determined by inductively coupled plasma atomic emission spectrometry.
Results. The established changes in the content of trace elements in the liver and kidneys of rats indicate the tissue specificity of the effect of fungicides, the active substances of which belong to the chemical class of triazoles. For the kidneys, a decrease in the content of vital trace elements indicates a metabolic disorder, and an increase in the content of Fe along with a decrease in the content of Zn, Mn indicates the activation of oxidative processes. For the liver, an increase in the content of trace elements upon the intake of fungicides characterizes the functional load on the organ.
Conclusions. The observed changes in the levels of trace elements in the kidneys and liver of rats exposed to fungicides belonging to the chemical class of triazoles may be due to metabolic shifts, as well as lead to dysfunctions and impaired regulation of intracellular signaling.
Key words: pesticides, microelements, atomic emission spectrometry, liver, kidney, imbalance
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