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Features of the structure and toxicological properties of new widely used nanopowder based on titanium

Features of the structure and toxicological properties of new widely used nanopowder based on titanium

ISSN 2223-6775 Ukrainian Journal of Occupational Health, Vol. 19, 2023, Supplement

https://doi.org/10.33573/ujoh2023.Suppl.373

Features of the structure and toxicological properties of new widely used nanopowder based on titanium

Yavorovsky O. P.1, Riabovol V. M.1, 2

1Bogomolets National Medical University, Kyiv, Ukraine

2State institution "Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine


Introduction.In the Institute of Materials Science Problems named after I.M. Frantsevich of the National Academy of Sciences of Ukraine, nanopowders based on titanium dioxide are synthesized by the author's method - thermal decomposition of metatitanic acid, for example, with the addition of 4 % nanosilver relative to titanium, which is characterized by high photocatalytic activity.

Objective. To investigate the features of the structural, morphological and toxicological properties of nano-TiO2 and nano-TiO2-Ag synthesized by thermal decomposition of metatitanic acid.

Materials and methods. The objects of our research were TiO2 and TiO2-Ag nanopowders obtained at the I. M. Frantsevich Institute for Problems of Materials Science of the National Academy of Sciences of Ukraine. The morphology and structure of the studied samples were determined using a transmission electron microscope JEM-1400 (JEOL, Japan) at a magnification of 2000 to 100 000 and a voltage of 80 kV according to the standard method. The structural and morphological features of the nanopowders were also studied using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray phase analysis (XPA), adsorption-structural volumetric method, infrared spectroscopy, Raman light scattering, and laser granulometry.

The results. According to the classification of the danger of chemicals in the air of the working area based on the listed LD50 values, nano-TiO2 corresponds to the 4th class (slightly dangerous), and nano-TiO2-Ag belongs to the 3rd class (moderately dangerous). TiO2 and TiO2-Ag nanopowders do not irritate the skin and have a weak irritating effect on the mucous membrane of the eye; can cause a weakly expressed sensitization effect. It was established that TiO2 nanopowder has weak cumulative properties. The immunotoxic effect of TiO2 and TiO2-Ag nanopowders on mononuclear blood cells and the damaging effect on germ cells of wild boars have been proven. For nano-TiO2, the estimated safe exposure levelis 0.3 mg/m3, and for nano-TiO2-Ag – 0.2 mg/m3.

Conclusions. The results of these studies were taken into account in the scientific justification and implementation of a complex of health-improving measures.

Keywords:nanomaterials, nanoparticles of metals and their compounds, electron microscopy, toxicology, cytokines, oxidative enzymes, hygiene regulation

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