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ASSOCIATION BETWEEN -308G/A-POLYMORPHISM OF TNF-a GENE AND RISK OF DEVELOPMENT OF PULMONARY FIBROSIS AND CHRONIC NONSPECIFIC PULMONARY DISEASE IN WORKERS OF ASBESTOS-CEMENT ENTERPRISES

ASSOCIATION BETWEEN -308G/A-POLYMORPHISM OF TNF-a GENE AND RISK OF DEVELOPMENT OF PULMONARY FIBROSIS AND CHRONIC NONSPECIFIC PULMONARY DISEASE IN WORKERS OF ASBESTOS-CEMENT ENTERPRISES

3(19) '2009

https://doi.org/10.33573/ujoh2009.03.059

Zhurakhivska N.V.

ASSOCIATION BETWEEN -308G/A-POLYMORPHISM OF TNF-a GENE AND RISK OF DEVELOPMENT OF PULMONARY FIBROSIS AND CHRONIC NONSPECIFIC PULMONARY DISEASE IN WORKERS OF ASBESTOS-CEMENT ENTERPRISES

SI «Iinstitute for Occupational Health of the Academy of Medical Sciences of Ukraine»

Full article (PDF), UKR

Association of -308G/A-polymorphism of tumor necrosis factor-alpha (TNF-a) gene with the development of chronic non¬specific pulmonary disease and pulmonary fibrosis has been investigated in populations of workers of asbestos-cement enter¬prises.TNF-a alleles polymorphism was studied in 93 healthy subjects (control group) and 116 patients with pulmonary pathology (a case group). They had minimum 5 years of work experience at asbestos-cement enterprises. A case group included 71 per¬sons with pulmonary fibrosis and 45 persons with chronic nonspecific pulmonary disease. The presence of A and G alleles was analyzed by PCR method and restriction fragment-length polymorphism (RFLP).The frequency of A and G alleles in the control group was not significantly different from patients with pulmonary fibrosis and chronic nonspecific pulmonary disease (p > 0,05). The significant frequencies of TNF-a genotypes in the controls and in groups of patients were not found (p > 0,05).The obtained data allow to conclude the lack of association of -308G/A-polymorphism of TNF-a gene with the chronic non¬specific pulmonary disease and pulmonary fibrosis development in workers of asbestos-cement enterprises in Ukraine.

Key words: chronic nonspecific pulmonary disease, pulmonary fibrosis, chrysotile asbestos, tumor necrosis factor-alpha, TNF-alpha gene, -308G/A-polymorphism

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